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Xu Zhang, Huanhuan Yang, Xinlei Wang, Wen Song, Zhaojie Cui
《环境科学与工程前沿(英文)》 2018年 第12卷 第4期 doi: 10.1007/s11783-018-1059-2
SFE-GC system is established for flavonols assessment. Optimal parameters of SFE-GC are evaluated and determined. Quercetin and kaempferol are detected in plant under heavy metal stress. Gene expression analysis shows consistent regularity with content of flavonols. ROS level is applied for elaborating the plant resistance status.
关键词: Flavonols Heavy metal Supercritical carbon dioxide extraction (SFE) GC Plant resistance
Impacts of advanced treatment processes on elimination of antibiotic resistance genes in a municipal
Lian Yang, Qinxue Wen, Zhiqiang Chen, Ran Duan, Pan Yang
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1116-5
The distributions of ARGs were monitored in a WWTP in Harbin during six months. CASS had the best removal efficacy of ARGs compared to other processes in the WWTP. UV disinfection could effectively control the HGT. AGAC significantly remove ARGs and organics due to its high absorption capacity. Combination of ozone and AGAC significantly improve removal of ARGs and organics.
关键词: Antibiotic resistance genes (ARGs) Wastewater treatment plant (WWTP) Ultraviolet (UV) Ozonation Granular activated carbon (GAC)
Xiaojun GU, Xiuzhong SU, Jun WANG, Yingjie XU, Jihong ZHU, Weihong ZHANG
《机械工程前沿(英文)》 2020年 第15卷 第4期 页码 547-557 doi: 10.1007/s11465-020-0595-1
关键词: carbon fiber reinforced polymer composite shape memory alloy wire impact resistance drop-weight test finite element simulation
HU Kexu, HE Guisheng, LU Fan
《结构与土木工程前沿(英文)》 2007年 第1卷 第4期 页码 399-404 doi: 10.1007/s11709-007-0054-7
Prevalence of antifolate drug resistance markers in in China
《医学前沿(英文)》 2022年 第16卷 第1期 页码 83-92 doi: 10.1007/s11684-021-0894-x
关键词: drug resistance antifolates molecular markers Plasmodium vivax China
Metagenomic analysis on resistance genes in water and microplastics from a mariculture system
《环境科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 4-4 doi: 10.1007/s11783-021-1438-y
Microplastics existing widely in different matrices have been regarded as a reservoir for emerging contaminants. Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs). However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system at the presence of microplastics is needed.
关键词: Antibiotic resistance genes Metal resistance genes Metagenomic analysis Microplastics Mariculture
Taking advantage of drug resistance, a new approach in the war on cancer
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《医学前沿(英文)》 2018年 第12卷 第4期 页码 490-495 doi: 10.1007/s11684-018-0647-7
Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.
关键词: cancer drug resistance genetic screens senescence targeted therapy
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors
《医学前沿(英文)》 2022年 第16卷 第5期 页码 701-713 doi: 10.1007/s11684-022-0951-0
关键词: acquired resistance EGFR inhibitor apoptosis lung cancer
Steam reforming of toluene as a tar model compound with modified nickel-based catalyst
Omeralfaroug KHALIFA, Mingxin XU, Rongjun ZHANG, Tahir IQBAL, Mingfeng LI, Qiang LU
《能源前沿(英文)》 2022年 第16卷 第3期 页码 492-501 doi: 10.1007/s11708-021-0721-8
关键词: catalytic steam reforming tar model compound Ni-based catalyst carbon resistance
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
《农业科学与工程前沿(英文)》 2020年 第7卷 第3期 页码 329-332 doi: 10.15302/J-FASE-2020333
The use of antibiotics in human medicine and animal husbandry has resulted in the continuous release of antibiotics into the environment, which imposes high selection pressure on bacteria to develop antibiotic resistance. The spread and aggregation of antibiotic resistance genes (ARGs) in multidrug-resistant pathogens is one of the most intractable clinical challenges. Numerous studies have been conducted to profile the patterns of ARGs in agricultural ecosystems, as this is closely related to human health and wellbeing. This paper provides an overview of the transmission of ARGs in agricultural ecosystems resulting from the application of animal manures and other organic amendments. The future need to control and mitigate the spread of antibiotic resistance in agricultural ecosystems is also discussed, particularly from a holistic perspective, and requires multiple sector efforts to translate fundamental knowledge into effective strategies.
关键词: agroecosystem antibiotic resistance public health soil-plant system
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1342-x
• SMX addition had negative effect on acetoclastic methanogens in mesophilic AD.
关键词: Pig manure Antibiotics Anaerobic digestion Resistance genes Microbial community
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1124-5
Extracellular DNA structure damaged by chlorination was characterized. Integrity of extracellular ARG genetic information after chlorination was determined. Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs. Plasmid DNA/ARGs were less readily broken down than genomic DNA. The Bioanalyzer methodology effectively documented damage incurred to DNA.
关键词: Antibiotic resistance Antibiotic resistance genes (ARGs) Extracellular DNA/ARGs Chlorination
Insulin resistance and the metabolism of branched-chain amino acids
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 53-59 doi: 10.1007/s11684-013-0255-5
Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causes serious health problems with an increased risk of several common metabolic disorders. IR related metabolic disturbance is not restricted to carbohydrates but impacts global metabolic network. Branched-chain amino acids (BCAAs), namely valine, leucine and isoleucine, are among the nine essential amino acids, accounting for 35% of the essential amino acids in muscle proteins and 40% of the preformed amino acids required by mammals. The BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiency. Although increased circulating BCAA concentration in insulin resistant conditions has been noted for many years and BCAAs have been reported to be involved in the regulation of glucose homeostasis and body weight, it is only recently that BCAAs are found to be closely associated with IR. This review will focus on the recent findings on BCAAs from both epidemic and mechanistic studies.
关键词: branched-chain amino acids leucine isoleucine valine insulin resistance
Immunometabolism: a new dimension in immunotherapy resistance
《医学前沿(英文)》 2023年 第17卷 第4期 页码 585-616 doi: 10.1007/s11684-023-1012-z
关键词: immune cell immunometabolism metabolic reprogramming immunotherapy resistance tumor microenvironment immune checkpoint inhibitor
Characteristics of two transferable aminoglycoside resistance plasmids in
Chengjun Pu, Xiaoyan Gong, Ying Sun
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1119-2
pRKZ3 is a non-conjugative IncQ plasmid, while pKANJ7 is a conjugative IncX plasmid. The optimal mating time of pKANJ7 varied under different conditions. Both of the two transferable ARPs had little impact on the growth of their hosts. A relatively high level of fitness cost was observed for pKANJ7. The fitness cost of ARPs depended on their hosts.
关键词: Escherichia coli Characteristics Aminoglycoside resistance plasmids Transfer Persistence
标题 作者 时间 类型 操作
An extraction- assay system: Evaluation on flavonols in plant resistance to Pb and Cd by supercritical
Xu Zhang, Huanhuan Yang, Xinlei Wang, Wen Song, Zhaojie Cui
期刊论文
Impacts of advanced treatment processes on elimination of antibiotic resistance genes in a municipal
Lian Yang, Qinxue Wen, Zhiqiang Chen, Ran Duan, Pan Yang
期刊论文
Improvement of impact resistance of plain-woven composite by embedding superelastic shape memory alloy
Xiaojun GU, Xiuzhong SU, Jun WANG, Yingjie XU, Jihong ZHU, Weihong ZHANG
期刊论文
Experimental study on fire protection methods of reinforced concrete beams strengthened with carbon fiber
HU Kexu, HE Guisheng, LU Fan
期刊论文
Steam reforming of toluene as a tar model compound with modified nickel-based catalyst
Omeralfaroug KHALIFA, Mingxin XU, Rongjun ZHANG, Tahir IQBAL, Mingfeng LI, Qiang LU
期刊论文
Transmission of antibiotic resistance genes in agroecosystems: an overview
Jizheng HE, Zhenzhen YAN, Qinglin CHEN
期刊论文
swine manure with sulfamethoxazole and norfloxacin: Dynamics of microbial communities and evolution of resistance
期刊论文
Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
期刊论文